Development of a New Method for Simultaneous Quantitation of Plasma Concentrations of Voriconazole and Voriconazole <i>N</i>-Oxide Using Column-Switching LC-MS/MS and Its Application in Therapeutic Drug Monitoring

Background Voriconazole therapy for fungal infections usually continues several years and is often administered on an outpatient basis. Maintaining the voriconazole plasma concentration in therapeutic range highly important effective therapy; however, it difficult to obtain sufficient information assess outpatients. Therefore, we developed a method simultaneously measure concentrations of its major metabolite, N-oxide, rapid results after blood collection before medical consultation attain better understanding adherence drug-drug interactions voriconazole.